all over the news today.

Scientists have built the first synthetic genome by stringing together 147 pages of letters representing the building blocks of DNA.

The researchers used yeast to stitch together four long strands of DNA into the genome of a bacterium called Mycoplasma genitalium. They said it’s more than an order of magnitude longer than any previous synthetic DNA creation. Leading synthetic biologists said with the new work, published Thursday in the journal Science, the first synthetic life could be just months away — if it hasn’t been created already.

“We consider this the second in our three-step process to create the first synthetic organism,” said J. Craig Venter, president of the J. Craig Venter Institute where scientists performed the study, on Thursday during a teleconference. “What remains now that we have this complete synthetic chromosome … is to boot this up in a cell.”

This is what they actually did. Looks like an interesting application of TAR cloning in yeast (another link) — normally used for sequence selection — which itself is a significant extension of the YAC toolset.

I guess small artificial genomes are a practical reality now, but TAR cloning is really the key here, allowing a less restrictive abstraction of the join operation to be implemented. Nice.

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